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Season Regulars 4
Frank Welker
Scooby-Doo / Fred Jones (voice)
Grey DeLisle
Daphne Blake (voice)
Mindy Cohn
Velma Dinkley (voice)
Matthew Lillard
Norville 'Shaggy' Rogers (voice)
Guest Stars 18
Casey Kasem
Colton Rogers (voice)
Harlan Ellison
Self (voice)
Lewis Black
Mr. E / Ricky Owens (voice)
Tony Cervone
Gary (voice)
Clancy Brown
Evil Entity (voice)
Amy Acker
Nova (voice)
Kath Soucie
Nan Blake (voice)
Dee Bradley Baker
Kriegstaffebot (Voice)
John O'Hurley
Skipper Shelton (voice)
Tia Carrere
Judy Reeves (voice)
Tim Matheson
Brad Chiles (voice)
Vivica A. Fox
Cassidy Williams (voice)
Kate Higgins
Mayor Janet Nettles (voice)
Linda Cardellini
Marcie 'Hot Dog Water' Fleach (voice)
Mitch Watson
Ethan (voice)
Gary Cole
Mayor Fred Jones Sr. (voice)
Udo Kier
Professor Pericles (voice)
Patrick Warburton
Sheriff Bronson Stone (voice)